How Important Are Senior Year Grades? Ten Points!?

Hi, so I’m a first semester senior (second semester starting in a week), and I’m really concerned about my grades. I’ve kept a pretty solid GPA (As and Bs.. A to B ratio is like 6:4) throughout high school, all honors and APs. But this year, I’m taking 4 APs and 2 regular, and I’m getting a C in AP Calc. I’ve always gotten Bs in math, so it’s not too huge of a surprise, and I’m getting one B and 4 As, so I’m wondering.. it won’t hurt my chances of getting into my top choice, will it?
I’m applying to: UC Berkeley, LA, San Diego, Santa Barbara, Irvine, Davis. And to Columbia, Harvard, Case Western Reserve, USC, Boston College, NYU, Washington University. I go to a prestigious school and have decent extracurriculars, am 1st decile rank.
Thank youuu TT